Tetrapeptide-21
What is Tetrapeptide-21?
Tetrapeptide-21 is a synthetic tetrapeptide, a short chain of four amino acids engineered for cosmetic applications. It falls under the category of signal peptides commonly found in anti-aging serums, creams, and lotions targeting facial and body skin. In formulations, it works by interacting with skin cells, particularly fibroblasts, to support the production of extracellular matrix components like collagen and laminin. Originating from biotechnology processes using amino acid precursors, it mimics natural peptides in the dermis. This conditioning agent is typically included at trace levels to enhance product texture and contribute to skin's moisture retention and structural integrity without altering the skin barrier.
Benefits
Supports skin conditioning for smoother texture
May promote dermal matrix components for firmness
Non-comedogenic, suitable for acne-prone skin
Who It's For
A quick guide for who this ingredient may suit (and who should be cautious).
| Who May Benefit | Who Should Avoid |
|---|---|
| People with mature skin seeking conditioning peptides | People with known peptide sensitivities |
| Individuals using anti-aging serums and creams | Those preferring fragrance-free products if combined |
| Those preferring low-hazard cosmetic ingredients | Individuals avoiding novel synthetic ingredients |
Safety Notes
- Rated low hazard by EWG with score of 1
- Generally recognized as safe for topical use
Frequently Asked Questions about Tetrapeptide-21
What is Tetrapeptide-21 used for in skincare?
It serves as a skin conditioning agent in creams and serums to support texture and firmness.
Is Tetrapeptide-21 safe for sensitive skin?
It has a low EWG hazard score of 1 and non-comedogenic rating, indicating good tolerability.
Does Tetrapeptide-21 clog pores?
No, it has a comedogenic rating of 0, making it suitable for all skin types.