Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

What is Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate?

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate is a lab-synthesized lipopeptide, featuring a chain of amino acids (aminobutyroylvalylaminobutyric) connected via urea, with a tetradecyl lipid tail for enhanced skin penetration and trifluoroacetate as the counterion. Primarily used in anti-aging serums, creams, and moisturizers, it acts as a biomimetic signaling molecule. Upon application, it reaches fibroblasts in the dermis, mimicking natural cues to boost synthesis of high-molecular-weight hyaluronic acid—a moisture-retaining glycosaminoglycan—and proteoglycans like decorin, which help organize collagen fibers. This mechanism supports the skin's extracellular matrix, contributing to a fuller, more resilient appearance over consistent use in formulations.

Comedogenic Rating 0/5 Low risk of clogging pores
EWG Safety Rating 1 View on EWG →

Benefits

Supports skin's moisture retention by aiding hyaluronic acid production

Promotes a plumper skin look through proteoglycan enhancement

Assists in maintaining dermal structure for smoother texture

Who It's For

A quick guide for who this ingredient may suit (and who should be cautious).

Who May Benefit Who Should Avoid
Individuals with dehydrated skin seeking hydration support
Those with known peptide sensitivities
People with mature skin aiming for firmness
Individuals prone to contact allergies from synthetic ingredients
Those using anti-aging routines for matrix support
People with compromised skin barriers until stabilized

Safety Notes

  • Rated low hazard by environmental health databases
  • Non-comedogenic, unlikely to clog pores

Frequently Asked Questions about Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

What does this peptide do in skincare?

It signals skin cells to produce more hyaluronic acid and proteoglycans, aiding hydration and plumpness.

Is it safe for daily use?

Generally considered safe at cosmetic levels with low irritation potential from assessments.

Does it cause breakouts?

Rated non-comedogenic, suitable for acne-prone skin without pore-clogging risk.