Polyquaternium-65

What is Polyquaternium-65?

Polyquaternium-65 is a high molecular weight, water-soluble cationic copolymer, primarily composed of quaternized acrylamide and diallyldimethylammonium chloride units. This synthetic polymer belongs to the polyquaternium family of conditioning agents commonly found in rinse-off hair care formulations like shampoos and conditioners, as well as some leave-on skin products. Its positively charged structure enables it to bind electrostatically to the negatively charged surfaces of hair keratin or skin proteins, forming a protective film that reduces friction and static electricity. In emulsions, it strengthens the interface between oil and water phases, preventing separation and enhancing product texture. As a humectant, it draws moisture to the surface, supporting hydration without greasiness. Typical concentrations remain low to maintain efficacy without buildup.

Comedogenic Rating 0/5 Low risk of clogging pores
EWG Safety Rating 1 View on EWG →

Roles in Formulation

This ingredient serves the following purposes in cosmetic formulations:

Emulsion stabilizer
Improves emulsion robustness by preventing droplet coalescence and phase separation, often by thickening, structuring, or strengthening the interfacial layer.
Hair conditioning
Improves softness, shine, and manageability by reducing friction and static; commonly achieved with cationic agents, silicones, oils, or conditioning polymers.
Humectant
Attracts and holds water in the stratum corneum, boosting hydration and plumpness; commonly used in moisturizers, cleansers, and hair conditioners.

Benefits

Provides conditioning to hair by forming a smooth film that reduces tangles and static.

Stabilizes emulsions in creams and lotions, improving product consistency and shelf life.

Acts as a humectant to help maintain surface moisture on hair and skin.

Who It's For

A quick guide for who this ingredient may suit (and who should be cautious).

Who May Benefit Who Should Avoid
People with dry or frizzy hair seeking improved manageability.
Individuals with known allergies to quaternary ammonium compounds.
Individuals using emulsified skincare products for better texture.
People experiencing irritation from similar cationic polymers.
Those looking for lightweight hydration in hair care routines.
Those preferring silicone-free or polymer-free formulations.

Safety Notes

  • Rated low hazard by EWG with scores of 1 across categories.
  • Assessed as safe for use in cosmetics by Cosmetic Ingredient Review.

Frequently Asked Questions about Polyquaternium-65

What is Polyquaternium-65 used for?

It serves as a hair conditioner, emulsion stabilizer, and humectant in shampoos, conditioners, and moisturizers.

Is Polyquaternium-65 safe for skin?

Yes, it carries a low EWG hazard score and is deemed safe by cosmetic safety panels.

Does it clog pores?

It has a comedogenic rating of 0, making it suitable for acne-prone skin.