Palmitoyl Hexapeptide-52

What is Palmitoyl Hexapeptide-52?

Palmitoyl Hexapeptide-52 is a lab-synthesized lipopeptide composed of a six-amino-acid chain linked to palmitic acid, a common fatty acid. This structure improves its solubility in oils and ability to cross the skin barrier. It falls under the peptide category in cosmetics, typically featured in serums, creams, and anti-aging products. Functionally, it serves as a skin-conditioning agent, potentially aiding in maintaining skin barrier integrity and supporting hydration levels through interactions with skin cells. Derived entirely from chemical synthesis rather than natural sources, it is incorporated at trace levels in leave-on formulations to enhance product texture and skin feel without altering pH significantly.

Comedogenic Rating 0/5 Low risk of clogging pores
EWG Safety Rating 1 View on EWG →

Benefits

Contributes to skin conditioning in cosmetic products

Non-comedogenic, suitable for pore-friendly routines

Low hazard rating supports broad formulation use

Who It's For

A quick guide for who this ingredient may suit (and who should be cautious).

Who May Benefit Who Should Avoid
People incorporating peptides into daily skincare
Those with known peptide sensitivities
Individuals seeking conditioning agents in creams and serums
People experiencing reactions to synthetic lipopeptides
Users preferring low-risk cosmetic additives
Individuals avoiding novel cosmetic peptides

Safety Notes

  • Rated with minimal safety concerns by hazard databases
  • Unlikely to clog pores based on comedogenic assessments

Frequently Asked Questions about Palmitoyl Hexapeptide-52

What is Palmitoyl Hexapeptide-52?

A synthetic lipopeptide used as a skin conditioner in serums and creams to support skin feel.

Is it safe for daily use?

It carries a low hazard rating and shows no comedogenic concerns in assessments.

What products contain it?

Commonly found in anti-aging serums, moisturizers, and facial creams.