Palmitoyl Dipeptide-5 Diaminohydroxybutyrate

What is Palmitoyl Dipeptide-5 Diaminohydroxybutyrate?

Palmitoyl Dipeptide-5 Diaminohydroxybutyrate is a synthetically produced lipopeptide, chemically composed of palmitic acid esterified to a dipeptide featuring diaminohydroxybutyrate units. Developed through peptide chemistry, it originates from laboratory processes rather than natural sources. Commonly incorporated into facial serums, creams, and anti-aging formulations at low concentrations, it functions primarily as a skin conditioning agent per cosmetic ingredient databases like CosIng. Its lipidated structure improves solubility in oil-based vehicles and affinity for skin lipids, allowing it to integrate with the stratum corneum. There, it associates with extracellular matrix elements and hydrolases, aiding in skin barrier reinforcement and moisture retention without abrasive action. Safety profiles from regulatory reviews indicate broad compatibility in rinse-off and leave-on products.

Comedogenic Rating 0/5 Low risk of clogging pores
EWG Safety Rating 1 View on EWG →

Benefits

Supports skin conditioning in formulations

Non-comedogenic for clearer skin compatibility

Low hazard rating suitable for regular use

Who It's For

A quick guide for who this ingredient may suit (and who should be cautious).

Who May Benefit Who Should Avoid
People with dry or dehydrated skin
Those with rare peptide sensitivities
Users seeking peptide conditioners
People avoiding synthetic ingredients
Individuals with low-irritation needs
Anyone noting personal reactions

Safety Notes

  • Assessed as low hazard by EWG
  • Compatible with sensitive skin profiles

Frequently Asked Questions about Palmitoyl Dipeptide-5 Diaminohydroxybutyrate

What is Palmitoyl Dipeptide-5 Diaminohydroxybutyrate?

A lab-made lipopeptide used for skin conditioning in creams and serums.

Is it safe for daily use?

Yes, it holds a low hazard score from safety databases.

Does it clog pores?

No, it has a comedogenic rating of 0.