Oxidized Glutathione
What is Oxidized Glutathione?
Oxidized glutathione, known chemically as GSSG, is the oxidized dimer of glutathione, a tripeptide composed of glutamate, cysteine, and glycine that occurs naturally in human cells as part of the antioxidant system. In cosmetic formulations, it serves mainly in the skin conditioning and emollient categories. As an emollient, it adheres to the skin's surface, filling in micro-roughness to create a smoother texture and better product glide during application. As a skin conditioning agent, it supports the skin's outer layer by promoting a soft, flexible feel without penetrating deeply due to its size and polarity. Commonly included in creams, lotions, and serums at low levels, it enhances overall product sensory qualities and pairs well with humectants and occlusives to aid in surface hydration retention. Regulatory bodies like the EU CosIng database recognize it for these functions based on its biochemical stability and mild profile.
Roles in Formulation
This ingredient serves the following purposes in cosmetic formulations:
Benefits
Provides a softening effect by smoothing skin's surface irregularities.
Enhances product spreadability for a luxurious application feel.
Supports skin flexibility and comfort through conditioning action.
Who It's For
A quick guide for who this ingredient may suit (and who should be cautious).
| Who May Benefit | Who Should Avoid |
|---|---|
| Individuals with dry or rough skin seeking surface smoothness. | People with known allergies to glutathione derivatives. |
| Users looking for emollient-enhanced moisturizers. | Individuals sensitive to peptide-based ingredients. |
| Those preferring gentle conditioning ingredients in daily routines. | Those preferring strictly anhydrous formulations. |
Safety Notes
- Rated low hazard by EWG with scores of 1 across concerns.
- Non-comedogenic, unlikely to clog pores.
Frequently Asked Questions about Oxidized Glutathione
What is oxidized glutathione?
The oxidized form of glutathione, a natural tripeptide, used in skincare for emollient and conditioning properties.
Is it safe for daily use?
Yes, it has a low hazard rating and is suitable for most skin types in cosmetic products.
Does it clog pores?
No, it has a comedogenic rating of 0, making it non-pore-clogging.