Ketoglutaric Acid

What is Ketoglutaric Acid?

Ketoglutaric acid, also called 2-oxoglutaric acid, is a dicarboxylic acid integral to cellular metabolism via the Krebs cycle. Derived synthetically or from natural fermentation processes for cosmetic use, it belongs to the category of organic acids employed in personal care formulations, particularly deodorants and body products. In skincare and cosmetics, it functions by donating or accepting protons to adjust and stabilize pH levels, ensuring optimal performance of other ingredients and product efficacy. As a buffering agent, it resists pH fluctuations from environmental factors or ingredient interactions. Additionally, it contributes to odor management by potentially neutralizing malodorous compounds or supporting antimicrobial activity without harsh chemicals. Its mild acidic nature allows subtle fragrance enhancement while prioritizing formulation balance and user sensory experience.

Comedogenic Rating 0/5 Low risk of clogging pores
EWG Safety Rating 1 View on EWG →
PubChem View on PubChem →

Roles in Formulation

This ingredient serves the following purposes in cosmetic formulations:

Deodorant agent
Targets malodor by neutralizing odor molecules, inhibiting odor-causing microbes, or adding fragrance notes to improve underarm and body freshness.
Fragrance ingredient
Contributes scent character and/or masks base odors, shaping the overall sensory experience of the formula (subject to allergen and IFRA considerations).
PH adjuster
Raises or lowers pH to the target range, supporting ingredient performance, preservative efficacy, stability, and user comfort.
Deodorant
Helps control body odor by reducing odor-causing bacteria and/or neutralizing or masking malodor, without necessarily reducing sweat production.
Buffering agent
Maintains the pH stability of a formulation.

Benefits

Supports stable pH for better ingredient performance and product shelf life.

Helps manage body odor through neutralization or microbial control in deodorants.

Non-comedogenic, suitable for use without clogging pores.

Who It's For

A quick guide for who this ingredient may suit (and who should be cautious).

Who May Benefit Who Should Avoid
Individuals seeking gentle odor control in daily hygiene products.
People with known allergies to organic acids, pending patch testing.
Users preferring pH-balanced formulations for skin comfort.
Those experiencing irritation from acidic ingredients in past products.
Those with normal to sensitive skin looking for low-risk buffering ingredients.
Individuals with very dry or compromised skin barriers during initial use.

Safety Notes

  • Rated low hazard by EWG, indicating minimal health concerns in typical cosmetic concentrations.
  • Non-comedogenic with a rating of 0, unlikely to contribute to acne.

Frequently Asked Questions about Ketoglutaric Acid

What does ketoglutaric acid do in skincare?

It adjusts pH, buffers formulations, and aids odor control in deodorants and body products.

Is ketoglutaric acid safe for sensitive skin?

It has a low EWG rating and is non-comedogenic, but patch test for personal tolerance.

Can it cause breakouts?

With a comedogenic rating of 0, it is unlikely to clog pores.