Disodium Guanylate

What is Disodium Guanylate?

Disodium Guanylate is the disodium salt of guanosine 5'-monophosphate, a naturally occurring ribonucleotide found in yeast extracts and animal tissues. It belongs to the nucleotide family and is produced via fermentation or chemical synthesis for use in cosmetics. Commonly featured in moisturizers, serums, and conditioners, it acts as a humectant by drawing moisture to the skin's surface layers, an emollient by smoothing roughness and enhancing product spreadability, and a skin conditioning agent by supporting barrier flexibility. Its water-binding properties help maintain hydration balance without greasiness, making it suitable for daily skincare formulations.

Comedogenic Rating 0/5 Low risk of clogging pores
EWG Safety Rating 1 View on EWG →

Roles in Formulation

This ingredient serves the following purposes in cosmetic formulations:

Emollient
Softens and smooths skin by filling in surface roughness and improving slip; can also help reduce moisture loss when paired with occlusives and film formers.
Humectant
Attracts and holds water in the stratum corneum, boosting hydration and plumpness; commonly used in moisturizers, cleansers, and hair conditioners.
Skin conditioning agent
Maintains skin softness, smoothness, and flexibility.

Benefits

Supports skin hydration by attracting and retaining moisture.

Softens and smooths skin texture for a supple feel.

Promotes overall skin comfort and flexibility.

Who It's For

A quick guide for who this ingredient may suit (and who should be cautious).

Who May Benefit Who Should Avoid
People with dry or dehydrated skin seeking gentle moisture.
Rare cases of nucleotide sensitivity.
Individuals looking for non-greasy conditioning in routines.
People with known allergies to yeast-derived components.
Those preferring mild ingredients in daily skincare.
No broad restrictions based on common use.

Safety Notes

  • Rated low hazard by safety assessments for cosmetic use.
  • Minimal irritation potential in typical concentrations.

Frequently Asked Questions about Disodium Guanylate

What does Disodium Guanylate do in skincare?

It hydrates by drawing water to skin, softens surface, and conditions for smoothness.

Is it safe for sensitive skin?

Yes, it shows low irritation potential and suits most skin types.

Where is it commonly found?

In moisturizers, serums, and conditioners for hydration support.