Dipalmitoyl Hydroxyproline

What is Dipalmitoyl Hydroxyproline?

Dipalmitoyl Hydroxyproline is a synthetic lipoamino acid, formed by esterifying hydroxyproline—an amino acid found in collagen—with two palmitic acid chains. This modification creates a lipid-soluble molecule that enhances skin and hair compatibility. Primarily used in skincare creams, lotions, serums, and hair care formulations like conditioners and styling aids. It functions by depositing a lightweight film on the skin surface to lock in moisture and promote suppleness, while interacting with hair cuticles to minimize friction. In products, it disperses evenly in emulsions, aiding texture and stability. Its amphiphilic nature allows mild penetration to support barrier function without heaviness, making it suitable for daily routines focused on comfort and manageability.

Comedogenic Rating 0/5 Low risk of clogging pores
EWG Safety Rating 1 View on EWG →
PubChem View on PubChem →

Roles in Formulation

This ingredient serves the following purposes in cosmetic formulations:

Skin conditioning agent
Maintains skin softness, smoothness, and flexibility.
Antistatic agent
Reduces static electricity and flyaways by improving surface conductivity, enhancing hair manageability and smoothness in conditioners and styling products.
Hair conditioning
Improves softness, shine, and manageability by reducing friction and static; commonly achieved with cationic agents, silicones, oils, or conditioning polymers.

Benefits

Enhances skin softness and flexibility for a smoother feel.

Improves hair shine and manageability by reducing friction.

Acts as an antistatic agent to control flyaways in hair products.

Who It's For

A quick guide for who this ingredient may suit (and who should be cautious).

Who May Benefit Who Should Avoid
Individuals with dry or rough skin seeking hydration.
Those with known sensitivity to fatty acid esters.
People with frizzy or static-prone hair.
People experiencing reactions to amino acid derivatives.
Users wanting lightweight conditioning in daily products.
Individuals preferring fully natural or minimalist ingredients.

Safety Notes

  • Considered low hazard with minimal risk of irritation.
  • Non-comedogenic, unlikely to clog pores.

Frequently Asked Questions about Dipalmitoyl Hydroxyproline

What does Dipalmitoyl Hydroxyproline do in products?

It conditions skin for softness and hair for shine while reducing static electricity.

Is it suitable for sensitive skin?

Generally low irritation potential, but patch test recommended.

Does it cause breakouts?

Rated non-comedogenic with a 0 rating, safe for acne-prone skin.