Ceramide 6-Ii

Ceramide / Barrier Lipid

What is Ceramide 6-Ii?

Ceramide 6-II is a synthetic sphingolipid mimicking ceramides in the human stratum corneum, featuring a phytosphingosine base linked to a hydroxy fatty acid chain. Produced via chemical synthesis or yeast fermentation, it falls under skin-identical emollients in cosmetics. Typically found in moisturizers, serums, and restorative creams targeting dry or sensitive skin, it works by inserting into the skin's lipid bilayers. This integration bolsters the mortar-like structure between skin cells, helping to seal gaps, reduce water evaporation, and maintain barrier cohesion. As a conditioning agent, it enhances skin suppleness and resilience without pore-clogging effects, supporting daily protection against environmental stressors.

Comedogenic Rating 0/5 Low risk of clogging pores
EWG Safety Rating 1 View on EWG →

Benefits

Reinforces the skin's protective lipid barrier

Promotes moisture retention within the skin

Conditions skin for improved smoothness and comfort

Who It's For

A quick guide for who this ingredient may suit (and who should be cautious).

Who May Benefit Who Should Avoid
People with dry or dehydrated skin
Those with rare allergies to synthetic lipids
Individuals with compromised skin barriers
People experiencing acute skin irritation
Users of sensitive skin formulations
Individuals preferring strictly botanical ingredients

Safety Notes

  • Low hazard rating suitable for broad use
  • Non-comedogenic, unlikely to clog pores

Frequently Asked Questions about Ceramide 6-Ii

What does Ceramide 6-II do in skincare?

It embeds in the skin's lipid matrix to support barrier function and moisture balance.

Is Ceramide 6-II safe for daily use?

Yes, it carries a low safety rating and suits most skin types without irritation concerns.

Can Ceramide 6-II clog pores?

No, it has a comedogenic rating of zero, making it suitable for acne-prone skin.